Home>Depression Medications
Treatment for depression includes: Psychotherapy / Medication
Antidepressant medications have been in use for many years. Three main classes of drugs have been traditionally used to control depression. The first group is known as the monoamine oxidase inhibitors (MAOIs). These drugs were developed early in the search for antidepressant medications and have fallen out of favor as the treatment of choice in recent years, except for small groups of patients who may still benefit from their use. The MAOIs work by inhibiting an enzyme involved in the breakdown of the monoamines serotonin and norepinephrine. Persons taking these drugs may experience unpleasant side effects and must follow certain dietary guidelines and restrictions to avoid foods containing the substance tyramine (found in cheeses, wines, and pickles and in some medications). Tyramine-containing foods can bring on a severe episode of hypertension when combined with MAOI use. Except in the more severe depressions, and bipolar depression, medication is usually an option, rather than a necessity. Antidepressant medication does not cure depression, it only helps you to feel better by controlling certain symptoms. If you are depressed because of life problems, such as relationship conflicts, divorce, loss of a loved one, job pressures, financial crises, serious medical problems in yourself or a family member, legal problems, or problems with your children, taking a pill will not make those problems go away.
The tricyclic antidepressants (TCAs) were developed after the MAOIs and inhibit the uptake of norepinephrine and serotonin, increasing the availability (and activity) of both these chemicals in the brain. Because these drugs have a nonspecific action and also prolong the action of other chemicals in the brain known as histamine and acetylcholine, certain side effects are commonly observed with TCAs. These include dry mouth, a sedative effect, dizziness, constipation, changes in sexual function, rapid heartbeat, weight gain, or blurred vision.
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